EXTENDED REPORT FGF2 induces RANKL gene expression as well as IL1β regulated MHC class II in human bone marrow-derived mesenchymal progenitor stromal cells
نویسندگان
چکیده
Departments of Surgery and of Biomedicine, University Hospital Basel, Basel, Switzerland Department of Rheumatology, University Hospital Basel, Basel, Switzerland Department of Biomedicine, Signal Transduction, University Hospital Basel, Basel, Switzerland Orthopaedic Department, Osteoarthritis Research Center, University Hospital Basel, Basel, Switzerland Department of Biomedicine, Developmental and Molecular Immunology, University of Basel, Basel, Switzerland
منابع مشابه
FGF2 induces RANKL gene expression as well as IL1β regulated MHC class II in human bone marrow-derived mesenchymal progenitor stromal cells.
OBJECTIVE Human bone marrow mesenchymal stromal cells (hBM-MSC) are being applied in tissue regeneration and treatment of autoimmune diseases (AD). Their cellular and immunophenotype depend on isolation and culture conditions which may influence their therapeutic application and reflect their in vivo biological functions. We have further characterised the phenotype induced by fibroblast growth ...
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Objective(s) The use of co-culture cells as well as extra cellular matrix are among those strategies that have been employed to direct mesenchymal stem cell (MSC) bone differentiation in culture. In this regard, there is no study considering the effects of Matrigel on mesenchymal stem cell (MSC) in vitro bone differentiation. This was the subject of the present study. Materials and Methods ...
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Human mesenchymal stem cells (hMSCs), which also called mesenchymal stromal cells, are multipotent stem cell. Human MSCs typically are positive for the surface markers CD44, CD73, CD90, CD105, CD106, and also negative for hematopoietic markers CD34 and CD45.These cells can be isolated from postnatal bone marrow, adipose tissue, placenta, and scalp tissue, as well as from various fetal tissues. ...
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